3The objectives of the treatment are the repigmentation and the stabilization of the depigmentation process. #Vitiligo universalis freeAmong the known non-genetic hypotheses, the most important are: autoimmune destruction of melanocytes, intrinsic defect in the structure and function of melanocytes, imperfect defense against free radicals, and reduction of melanocyte survival. Studies suggest that vitiligo is a non-Mendelian, polygenic inheritance disease, with recurrence of 20% to 30% among first-degree relatives. It is a multifactorial disorder related to genetic and non-genetic factors. The physiopathological mechanism of vitiligo is not yet clearly understood. The disease can be classified according to the distribution of the lesions as: localized (focal, segmental and mucosal) and generalized (acrofacial, vulgaris and universalis). 2 The disorder is characterized by circumscribed depigmented patches that vary in number and size. It can occur at any period of a person’s life, with the mean age of onset being 20 years old. 1,2Vitiligo affects 0.5% to 2% of the general population worldwide, with no distinction for gender or ethnicity. #Vitiligo universalis skinMelanocytes disappear from the skin surrounded by mechanisms that have not yet been fully identified. Vitiligo is an acquired idiopathic disorder characterized by the selective destruction of functional epidermal melanocytes. Keywords: STEM CELLS VITILIGO THERAPEUTICS The vitiligo affected area was relatively decreased in density with a rare repigmentation pattern. We report the case of a 53-year-old female patient who underwent underwent experimental stem cell therapy with autologous biologically expanded stem cells isolated from hair follicle, holding three sessions with three months apart. The goals of treatment are repigmentation of vitiligo and stabilization of depigmentation process. Vitiligo affects around 0,5% about 0.5% -2% of the general population worldwide, and is not observed preference for sex and ethnicity. It is characterized by defilements and circumscribed depigmented patches. Vitiligo is a hypopigmentation disorder that is characterized by macules and selective destruction of functional epidermal melanocytes.
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